A new route have been developed for synthesis of 6,8-dichloro-3-[(E)-1,2-diphenylethenyl] [1,2,4]triazolo[3,4-b][1,3]benzoxazole derivatives 7(a-f). The compound (3) treating with Phenylacetic acid (4) in ethanol yield3-benzyl-6,8-dichloro[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5). The compound (5) further reacting with different aromatic aldehydes to form target molecules 7(a-f) by Knoevenagel condensation method. The obtained products have been characterized by IR, 1H NMR, 13C NMR and Mass spectral studies. The synthesized molecules subjected for antimicrobial and antioxidant activity to know the efficacy of molecules.
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